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Amy must confront who she has become after the tragedy that struck her family seven years ago. Sonya and TJ disagree on how to treat a sick Marine, and Amy and Jake make a life-changing discovery about an Alzheimer’s patient.

Amy and Sonya endeavor to help a teen in need of a bone marrow transplant and his younger brother whose own health issues jeopardize his disability to donate. Jake deals with a fainting bride and her worried groom. Michael struggles with a secret he’s been keeping.

It’s a race against time as Amy and Jake try to uncover the cause of a unique patient’s worsening condition. Gina treats a quirky hypochondriac, and Amy makes a shocking discovery about her pre-accident love life.

Sonya wrestles with treating a guy from her past and must rely on Amy to help her. Richard deals with a family situation. Jake and TJ debate the moral implications of a diagnosis.

Amy, finally allowed to practice medicine again without supervision, struggles to diagnose her most complicated patient yet: TJ’s Dad. Sonya and Jake treat a single mom who’s reluctant to stay in the hospital. Richard tires to contain the truth about Dixon.

A mass casualty event requires all hands on deck at Westside Hospital. Amidst the chaos, Gina deals with a devastating revelation and Amy’s forced to confront her demons.