The Powerpuff Girls face their greatest challenge in this 10th anniversary special episode. There exists a Key to the World, which is handed from city to city on an annual basis. Whoever possesses the key rules over the entire world. When the key is delivered to Townsville, every villain in Townsville attempts to retrieve it. When the girls procure it for themselves, they quickly get sucked into a power struggle, fighting the villains and themselves over who gets to rule the world.
Cathy Cavadini
Blossom (voice)
Tara Strong
Bubbles / Alarm System (voice)
E. G. Daily
Buttercup (voice)
Tom Kenny
Narrator / Mayor / Dove (voice)
Tom Kane
Professor / Him / Talking Dog (voice)
Roger L. Jackson
Mojo Jojo (voice)
Jennifer Martin
Ms. Bellum (voice)
Kevin Michael Richardson
Fish Balloon (voice)
Jeff Bennett
Ace / Prisoner / Concerned Citizen (voice)
Jim Cummings
Fuzzy Lumpkins (voice)
Jennifer Hale
Princess (voice)
